Activated recombinant factor VII for refractory bleeding during extracorporeal membrane oxygenation
نویسندگان
چکیده
منابع مشابه
Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation.
Bleeding remains a potential complication for patients requiring extracorporeal life support systems. Recombinant activated factor VII (rFVIIa) is one of the drugs used in controlling bleeding. Its use is generally found to be safe. We report a paediatric patient who developed fatal thrombosis with the use of rFVIIa whilst on extracorporeal membrane oxygenation and discuss the possible factors ...
متن کاملSalvage use of activated recombinant factor VII in the management of refractory bleeding following cardiac surgery
BACKGROUND Refractory post cardiopulmonary bypass (CPB) bleeding continues to cause concern for cardiac surgeons and intensivists. Massive postoperative hemorrhage following CPB is multifactorial and not fully understood, and it is also associated with increased mortality and morbidity. Activated recombinant factor VII (rFVIIa) has emerged as possible salvage medication in refractory post cardi...
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(1) Recombinant activated factor VII (rFVIIa) is licensed in Canada for the prevention and treatment of bleeding in hemophiliacs, but it is increasingly used to control bleeding in non-hemophilic patients during surgery, or during treatment for severe trauma or intracerebral hemorrhage (ICH). (2) In one clinical trial, there was a significant reduction in mortality among patients with ICH treat...
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Materials and Methods Data were collected from a prospectively maintained database and retrospective chart review. The data collected included maternal and neonatal characteristics, aetiology of respiratory failure, oxygenation index (OI) and alveolararterial oxygen gradient (AaDO2) prior to undergoing ECMO, age of commencing ECMO, duration of ECMO, complications, duration of hospitalisation an...
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ژورنال
عنوان ژورنال: Journal of Thoracic and Cardiovascular Surgery
سال: 2004
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(04)00014-5